mechanistic
Analysis v1
Even though EGCG (a compound in green tea) sticks really well to a human enzyme that adds methyl groups, its shape doesn’t line up right with the tiny magnesium ion the enzyme needs to work—so it can’t be properly methylated, making it a bad fit for the job.
Evidence from Studies
Supporting (1)
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Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (–)-epigallocatechin-3-O-gallate
Computational/Algorithm Study
2008 FebEGCG sticks really well to the enzyme, but it doesn’t line up right to let the enzyme add a methyl group to it—so even though it’s tightly stuck, the enzyme can’t easily change it.
Contradicting (0)
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No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.