When you have too much 'bad' cholesterol (LDL) in your blood, it sticks to the walls of your arteries and builds up like gunk, making them narrow and stiff — which raises your chance of having a...

Pro

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Evidence from Studies

Supporting (5)

Community contributions welcome

Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis.

Systematic Review With Meta-Analysis

Human

2016 Sep 27

Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study

Chapter 29 – The Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC)

Genetically elevated LDL cholesterol burden results into reduced progenitor cells with impaired endothelial forming potential

Epidemiological approaches to heart disease: the Framingham Study.

1951 Mar

Contradicting (2)

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PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor

Cohort Study

Human & Animal & In Vitro

2024 Mar 30

The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development.

Cohort Study

Human & Animal

2020 Oct 21

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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