mechanistic
Analysis v1
Strong Opposition
When you have more vitamin D in your body, your fat cells send out more of a signal called leptin, which tells your brain you’re full and don’t need to store more fat—so you might gain less fat over time.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
This study shows that taking a lot of vitamin D helps your body use extra calories to build muscle instead of storing them as fat, partly by making a hormone called leptin work better to tell your brain you’re full.
Contradicting (1)
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Community contributions welcome
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Retinoic acid and vitamin D(3) powerfully inhibit in vitro leptin secretion by human adipose tissue.
Cross-Sectional Study
Human
2001 AugThe study found that vitamin D actually lowers the amount of leptin made by fat cells, but the claim says vitamin D raises leptin — so the study proves the claim wrong.
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.