EPA and DHA omega-3 fatty acids lower levels of chronic inflammation that contribute to insulin resistance.

Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial

·Randomized Controlled Trial·Human·2025

This study found that taking fish oil with EPA and DHA lowered inflammation and improved how the body uses insulin in burn patients. That means it supports the idea that these omega-3s help reduce the chronic inflammation that makes insulin resistance worse.

Effects of Omega-3 Fatty Acids Associated with Antioxidant Vitamins in Overweight and Obese Children

·Randomized Controlled Trial·Human·2023

Kids who took a supplement with omega-3s (EPA and DHA) and some vitamins had less insulin resistance and better fat-related hormones, which means their bodies were less inflamed and handled sugar better.

Randomized controlled trial of omega-3 fatty acid supplementation and probiotic therapy on insulin sensitivity in obesity-related metabolic syndrome

·Randomized Controlled Trial·Human

The study found that taking omega-3 fatty acids lowered body-wide inflammation and also improved how well the body responds to insulin, which supports the idea that these fats help reduce the inflammation that causes insulin problems.

Effect of prenatal EPA and DHA on maternal and cord blood insulin sensitivity: a secondary analysis of the mothers, omega 3, and mental health study

·Cohort Study·Human·2019

The study gave pregnant women omega-3 pills to see if they’d improve blood sugar control, but the pills didn’t help. Even though women with naturally higher omega-3 levels had slightly better blood sugar markers, taking the pills didn’t make that happen—so the pills don’t seem to work for this purpose.