Even after accounting for many other factors that could affect insulin sensitivity, the link between oral bacteria that convert nitrates to nitrites and better insulin sensitivity still holds true.
Scientific Claim
The association between nitrate-reducing oral bacteria and insulin resistance remains significant after adjusting for multiple potential confounders including age, sex, race, education, body mass index, smoking status, periodontal disease, and dietary patterns.
Original Statement
“After multivariable adjustment, a 1-SD increase in NO3TSS, was associated with a −0.09 (95% CI, −0.15 to −0.03) and −1.03 mg/dL (95% CI, −1.903 to −0.16) lower natural log-transformed homeostatic model assessment of insulin resistance and plasma glucose, respectively.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is observational and cross-sectional, so 'associated with' is the correct verb strength. The claim accurately reflects the statistical relationship after adjustment without implying causation.
Evidence from Studies
Supporting (1)
Association Between Nitrate‐Reducing Oral Bacteria and Cardiometabolic Outcomes: Results From ORIGINS