Even after accounting for other factors like sex and hepatitis, higher visceral fat was still linked to higher ALT levels in HIV patients with high liver enzymes.

Scientific Claim

In HIV-infected patients with elevated transaminases, the association between visceral adipose tissue and alanine aminotransferase remained significant after adjusting for sex, viral hepatitis, testosterone use, and limb fat (P=0.01).

Original Statement

“VAT remained significantly related to ALT (P = 0.01) when controlling for sex, viral hepatitis, testosterone use, and limb fat.”

From study:Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims. The language correctly describes the adjusted association without implying causation.

Evidence from Studies

Supporting (1)

Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV

Randomized Controlled Trial

Human

2017 Oct 23

Contradicting (0)

No contradicting evidence found

Source Study

Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV

Score: 62

DOI: 10.1097/QAD.0000000000001614

Similar Assertions

In HIV patients on placebo, losing visceral fat didn't lead to lower liver enzymes, unlike those taking tesamorelin.

92%

In people with HIV and belly fat, higher amounts of visceral fat were linked to higher liver enzyme levels even when accounting for other factors like sex and hepatitis.

87%

Whether HIV patients had hepatitis or not didn't change the link between losing visceral fat and improving liver enzyme levels.

86%

In HIV patients with belly fat, higher amounts of visceral fat were linked to higher liver enzyme levels at the start of the study.

84%

In people with HIV and belly fat, the amount of visceral fat didn't correlate with liver enzyme AST levels when other factors like sex and hepatitis were considered.

83%