If you're already fit and lift weights regularly, adding variety to your workouts or sticking to the same routine won't noticeably change the number of special muscle repair cells or their nuclei — your muscles stay pretty much the same on that front.
Context Details
Domain
exercise_science
Population
human
Subject
Satellite cell and myonuclei content in skeletal muscle of trained individuals
Action
do not change significantly
Target
after resistance training, whether standard or variable
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
Resistance training variable manipulations are less relevant than intrinsic biology in affecting muscle fiber hypertrophy
Even when people who already lift weights change up their routines—like using heavier weights or resting longer—the number of special muscle repair cells and nuclei in their muscles doesn’t really change. So, the study agrees with the claim.