If you're already fit and lift weights regularly, adding variety to your workouts or sticking to the same routine won't noticeably change the number of special muscle repair cells or their nuclei — your muscles stay pretty much the same on that front.

42

Pro

0

Against

Evidence from Studies

Supporting (1)

42

Community contributions welcome

42

Resistance training variable manipulations are less relevant than intrinsic biology in affecting muscle fiber hypertrophy

Randomized Controlled Trial

Human

2022 May

Even when people who already lift weights change up their routines—like using heavier weights or resting longer—the number of special muscle repair cells and nuclei in their muscles doesn’t really change. So, the study agrees with the claim.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Resistance training variable manipulations are less relevant than intrinsic biology in affecting muscle fiber hypertrophy

Score: 42

DOI: 10.1111/sms.14134

Similar Assertions

If you're already fit and lift weights, your muscle cells don't seem to add more helper cells or nuclei, even when you change up your routine—meaning those extra cells might not be needed to make your muscles bigger.

42

0

89%

Some people get much stronger and build more muscle from weight training than others—this might be because their muscle cells grow more new nuclei, but not every study agrees on this.

1

0

74%