When triglyceride emulsions like Intralipid are delivered directly into the intestine, they may cause minor damage to the intestinal lining, which is detected by a delayed release of LDH during...
Mechanism
Synthesis from 1 study
When fat is pumped straight into the intestine in an unnatural way, it slowly hurts the gut lining. This hurt sends pain signals to the brain, making the person feel bad and stop eating — not because they’re full, but because it hurts.
Most probable mechanism
When fat is pumped directly into the intestine in a way the body isn’t used to, it irritates the inner lining of the gut. This irritation slowly damages the surface cells, causing them to leak a substance called LDH. The damage also activates pain-sensing nerves in the gut, which send signals to the brain that make the person feel uncomfortable and stop eating — even if they’re not full.
Non-physiological intraintestinal infusion of triglyceride emulsions disrupts the integrity of the intestinal mucosal epithelium
Delayed release of lactate dehydrogenase (LDH) during saline washout reflects progressive epithelial cell membrane damage and loss of barrier function
Mucosal damage activates enteric nociceptors and vagal afferent nerves, generating aversive signals to the central nervous system
Aversive neural signaling suppresses appetite and reduces food intake independently of satiety hormones or nutrient sensing
Evidence from Studies
Supporting (1)
Community contributions welcome
Satiety from fat? Adverse effects of intestinal infusion of sodium oleate.
Contradicting (0)
Community contributions welcome
Gold Standard Evidence Needed
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