Even if you pump insulin into a healthy young person’s body and boost certain amino acids by 150%, their muscles still won’t grow more—because insulin needs other amino acids too to make muscle.

33

Pro

0

Against

Evidence from Studies

Supporting (1)

33

Community contributions welcome

33

Insulin does not stimulate muscle protein synthesis during increased plasma branched-chain amino acids alone but still decreases whole body proteolysis in humans

Randomized Controlled Trial

Human

2016 Oct 1

Even when they gave people extra branched-chain amino acids and insulin, their muscles didn’t build more protein—meaning insulin by itself isn’t enough to make muscles grow; they need other amino acids too.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Insulin does not stimulate muscle protein synthesis during increased plasma branched-chain amino acids alone but still decreases whole body proteolysis in humans

Score: 33

DOI: 10.1152/ajpendo.00120.2016

Similar Assertions

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Even if you have more branched-chain amino acids in your blood, insulin still works the same way to stop your muscles from breaking down — adding these amino acids doesn’t make insulin any better at protecting your muscles.

33

0

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Adequate dietary protein intake stimulates sufficient insulin secretion to maximize suppression of muscle protein breakdown, rendering additional carbohydrate intake redundant for insulin-mediated anabolic signaling.

0

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