If you only raise the levels of three specific amino acids in the blood—without boosting all the other important ones—your muscles won’t start building more protein, even if insulin is around to help.

33

Pro

0

Against

Evidence from Studies

Supporting (1)

33

Community contributions welcome

33

Insulin does not stimulate muscle protein synthesis during increased plasma branched-chain amino acids alone but still decreases whole body proteolysis in humans

Randomized Controlled Trial

Human

2016 Oct 1

Even when insulin is present and BCAA levels are raised, muscles didn't build more protein unless other amino acids were also present — so BCAA alone doesn't cut it.

Contradicting (0)

0

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Insulin does not stimulate muscle protein synthesis during increased plasma branched-chain amino acids alone but still decreases whole body proteolysis in humans

Score: 33

DOI: 10.1152/ajpendo.00120.2016

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