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Back to Study: Protein synthesis signaling in skeletal muscle is ...
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Strong Support

Even though drinking whey protein makes more building-block amino acids show up in the blood during extreme dieting, those amino acids don’t get the muscle to grow like they normally would.

32
Pro
0
Against

Evidence from Studies

Supporting (1)

32

Community contributions welcome

32

Protein synthesis signaling in skeletal muscle is refractory to whey protein ingestion during a severe energy deficit evoked by prolonged exercise and caloric restriction

Randomized Controlled Trial
Human
2019 Apr

Even when people drank whey protein while eating very little and exercising a lot, their blood amino acids went up — but their muscles didn’t respond by building more protein. So, more amino acids didn’t help them grow muscle under these extreme conditions.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Protein synthesis signaling in skeletal muscle is refractory to whey protein ingestion during a severe energy deficit evoked by prolonged exercise and caloric restriction

Score: 32
DOI: 10.1038/s41366-018-0174-2

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Even when people eat whey protein during extreme dieting and lots of exercise, their muscles stop responding to it like they normally would — the protein doesn’t trigger the usual growth signals.

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46
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