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Back to Study: Protein synthesis signaling in skeletal muscle is ...
mechanistic
Analysis v1
Strong Support

Even when people eat whey protein during extreme dieting and lots of exercise, their muscles stop responding to it like they normally would — the protein doesn’t trigger the usual growth signals.

32
Pro
0
Against

Evidence from Studies

Supporting (1)

32

Community contributions welcome

32

Protein synthesis signaling in skeletal muscle is refractory to whey protein ingestion during a severe energy deficit evoked by prolonged exercise and caloric restriction

Randomized Controlled Trial
Human
2019 Apr

Even when people drank whey protein after intense exercise and eating very little, their muscles didn’t respond to it like they normally would — the signal that tells muscles to grow was weakened, just like the claim said.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Protein synthesis signaling in skeletal muscle is refractory to whey protein ingestion during a severe energy deficit evoked by prolonged exercise and caloric restriction

Score: 32
DOI: 10.1038/s41366-018-0174-2

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When rats exercised and then ate a small amount of whey protein hydrolysate, their muscles built protein faster than when they ate regular whey protein at the same dose.

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