The Claim

In untrained men, resistance exercise volume does not significantly alter Akt or mTOR phosphorylation, indicating that these upstream regulators are saturated at low volumes and are not the primary determinants of volume-dependent signaling differences in p70S6k and S6.

Source: The degree of p70S6k and S6 phosphorylation in human skeletal muscle in response to resistance exercise depends on the training volume

What the research says

Challenges is higher

Challenge is ahead, but a single strong supporting study can change this.

Supports
0score
Challenges
53score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

When guys who don’t lift regularly do weight training, even doing more sets doesn’t change certain key muscle signals called Akt and mTOR—so those signals must already be maxed out at low workout levels, and something else is driving the bigger changes seen in other muscle signals.

See the scientific wording

In untrained men, resistance exercise volume does not significantly alter Akt or mTOR phosphorylation, indicating that these upstream regulators are saturated at low volumes and are not the primary determinants of volume-dependent signaling differences in p70S6k and S6.

What the research says

1 study

  1. Study: The degree of p70S6k and S6 phosphorylation in human skeletal muscle in response to resistance exercise depends on the training volume

    The study found that doing more sets of weightlifting didn’t change certain key muscle signals (Akt and mTOR), but did make other signals (p70S6k and S6) much stronger — meaning those other signals, not Akt/mTOR, are what respond to doing more work.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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