Even though high potassium lowers a kidney transporter in mice, this doesn't explain the blood pressure changes, suggesting other mechanisms are at play.

Scientific Claim

Chronic high dietary potassium supplementation in mice is associated with reduced sodium-chloride cotransporter (NCC) expression, but this reduction does not correlate with blood pressure changes.

Original Statement

“HCTZ did not significantly reduce BP during high K+ feeding, suggesting that the relationship between NCC and BP is 'disconnected' during chronic K+ feeding.”

From study:Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports correlational claims. The phrasing correctly states the lack of correlation using 'does not correlate' and avoids causal language.

Evidence from Studies

Supporting (1)

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Cohort Study

Animal

2023 Mar 8

Contradicting (0)

No contradicting evidence found

Source Study

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Score: 13

DOI: 10.1172/jci.insight.156437

Similar Assertions

When mice don't get enough potassium, their kidney transporter becomes more active and blood pressure rises, but a common blood pressure drug can lower it again.

88%

Whether mice get extra potassium for a few days or weeks, a key kidney transporter becomes less active.

84%

Long-term high potassium makes a kidney channel more active, and blocking that channel with a drug lowers blood pressure in mice.

80%

For a few days, extra potassium lowers mice's blood pressure, but after three weeks, it starts to raise it again.

79%

In mice eating normal salt, even though extra potassium slows down one salt-handling channel (NCC), it doesn't lower blood pressure because another channel (ENaC) starts pulling in more salt instead.

79%