For a few days, extra potassium lowers mice's blood pressure, but after three weeks, it starts to raise it again.

Scientific Claim

Short-term (4 days) potassium chloride supplementation in mice is associated with reduced systolic blood pressure, whereas chronic (3 weeks) supplementation is associated with increased systolic blood pressure.

Original Statement

“Short-term NS/+KCl significantly decreased, whereas chronic NS/+KCl feeding significantly increased SBP and DBP”

From study:Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports correlational claims. The phrasing uses 'associated with' for both effects and avoids causal language, matching the evidence level.

Evidence from Studies

Supporting (1)

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Cohort Study

Animal

2023 Mar 8

Contradicting (0)

No contradicting evidence found

Source Study

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Score: 13

DOI: 10.1172/jci.insight.156437

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