When mice eat a lot of potassium for three weeks, their blood pressure goes up mostly at night, no matter how much salt they eat or what form of potassium they consume.

Scientific Claim

Chronic high dietary potassium (5% K+) supplementation for 3 weeks in mice is associated with increased systolic blood pressure during the night, independent of sodium intake or the type of potassium anion.

Original Statement

“Three weeks of a high K+ diet (5% K+) increased BP (predominantly during the night) independently of dietary Na+ or anion intake.”

From study:Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is an observational cohort in mice with no randomization or blinding, so only associations can be claimed. The phrasing correctly uses 'associated with' without implying causation.

Evidence from Studies

Supporting (1)

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Cohort Study

Animal

2023 Mar 8

Contradicting (0)

No contradicting evidence found

Source Study

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Score: 13

DOI: 10.1172/jci.insight.156437

Similar Assertions

For a few days, extra potassium lowers mice's blood pressure, but after three weeks, it starts to raise it again.

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In mice eating normal salt, too much potassium (over 1.75% of their diet) makes their blood pressure go up during active hours, especially at high potassium levels like 5%, because of increased activity of certain kidney channels.

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When mice eat a lot of salt, adding a moderate amount of potassium lowers their blood pressure, showing that potassium's main benefit might be fighting high blood pressure caused by salt.

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Long-term high potassium makes a kidney channel more active, and blocking that channel with a drug lowers blood pressure in mice.

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Even though high potassium lowers a kidney transporter in mice, this doesn't explain the blood pressure changes, suggesting other mechanisms are at play.

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