In mice eating normal salt, too much potassium (over 1.75% of their diet) makes their blood pressure go up during active hours, especially at high potassium levels like 5%, because of increased activity of certain kidney channels.

When mice eat a lot of salt, adding a moderate amount of potassium lowers their blood pressure, showing that potassium's main benefit might be fighting high blood pressure caused by salt.

When mice eat a lot of salt, adding a moderate amount of potassium lowers their blood pressure by about 3.6 mmHg compared to eating the same high salt without extra potassium.

In mice, more potassium leads to more aldosterone in a straight-line way, but blood pressure rises sharply only when aldosterone hits a certain level (around 4040 pg/24h), then levels off.

When mice eat a lot of potassium for three weeks, their blood pressure goes up mostly at night, no matter how much salt they eat or what form of potassium they consume.

In mice eating normal salt, even though extra potassium slows down one salt-handling channel (NCC), it doesn't lower blood pressure because another channel (ENaC) starts pulling in more salt instead.