In mice, more potassium leads to more aldosterone in a straight-line way, but blood pressure rises sharply only when aldosterone hits a certain level (around 4040 pg/24h), then levels off.
Scientific Claim
In male mice, dietary potassium intake exhibits a linear relationship with aldosterone excretion (R²=0.98), while systolic blood pressure shows a sigmoidal correlation with aldosterone levels, with the steepest increase occurring at approximately 4040 pg/24h aldosterone excretion.
Original Statement
“On a NS intake, plasma K+ had a positive linear relationship to aldosterone excretion (R2 = 0.98, Fig. 5B). Aldosterone excretion was positively correlated to BP, with a sigmoidal relationship between 24 h aldosterone and dark phase SBP (Fig. 5C). A four-parameter logistic (4PL) curve demonstrated that the steepest rise in BP occurred with an aldosterone excretion of ~4040 pg per 24 h”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design supports correlational claims. The language accurately describes observed relationships without implying causation.
Evidence from Studies
Supporting (1)
Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC