Mice missing the AMPKα1 gene produce more aldosterone in their urine and have lower blood pressure than normal mice.

Scientific Claim

Mice with AMPKα1 knockout have higher urinary aldosterone excretion rates and reduced blood pressure.

Original Statement

“higher urinary aldosterone excretion rates and reduced blood pressure.”

From study:Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The abstract directly states the observation using 'higher' and 'reduced', which are appropriate for descriptive claims in an animal model.

Evidence from Studies

Supporting (1)

Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

Cohort Study

Animal

2017 Feb 1

Contradicting (0)

No contradicting evidence found

Source Study

Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

Score: 8

DOI: 10.1152/ajprenal.00169.2016

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