How Kidneys Use AMPK to Control Water and Salt
Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Plasma volume increased despite lower hematocrit
Normally fewer red blood cells would suggest lower blood volume, but plasma volume compensated to maintain total blood volume
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Plasma volume increased despite lower hematocrit
Normally fewer red blood cells would suggest lower blood volume, but plasma volume compensated to maintain total blood volume
Publication
Journal
American journal of physiology. Renal physiology
Year
2017
Authors
Yoskaly Lazo-Fernandez, Goretti Baile, Patricia Meade, P. Torcal, Laura Martínez, C. Ibañez, M. L. Bernal, B. Viollet, I. Giménez
Related Content
Claims (6)
Kidneys regulate blood volume by controlling sodium and water excretion.
When mice lack the AMPKα1 gene, their kidneys handle salt normally and produce less urine than usual.
Mice missing the AMPKα1 gene produce more aldosterone in their urine and have lower blood pressure than normal mice.
Even though these mice have less red blood cells, their blood plasma volume is higher than normal mice.
When mice lose both AMPKα1 and AMPKα2 in their kidneys, they lose too much water and salt in their urine.