descriptive
Analysis v1
8
0
When mice lose both AMPKα1 and AMPKα2 in their kidneys, they lose too much water and salt in their urine.
Scientific Claim
Mice with combined AMPKα1 deletion and renal-specific AMPKα2 knockdown exhibit reduced renal AMPK activity and a water- and salt-wasting phenotype.
Original Statement
“Combining this approach with the systemic deletion of AMPKα1 we achieved reduced renal AMPK activity, accompanied by a shift to a moderate water- and salt-wasting phenotype.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The abstract uses 'exhibit' and 'shift to' which are descriptive terms appropriate for observed changes in the study.
Evidence from Studies
Supporting (1)
8
8
Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.
Cohort Study
Animal
2017 Feb 1Contradicting (0)
0
No contradicting evidence found