Analysis Version
v1
History
Back to Study: Kidney-specific genetic deletion of both AMPK α-su...
descriptive
Analysis v1
8
Pro
0
Against

When mice lose both AMPKα1 and AMPKα2 in their kidneys, they lose too much water and salt in their urine.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The abstract uses 'exhibit' and 'shift to' which are descriptive terms appropriate for observed changes in the study.

Evidence from Studies

Supporting (1)

8
8

Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

Cohort Study
Animal
2017 Feb 1

Contradicting (0)

0
No contradicting evidence found

Source Study

Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

Score: 8
DOI: 10.1152/ajprenal.00169.2016

Similar Assertions

When mice lack the AMPKα1 gene, their kidneys handle salt normally and produce less urine than usual.

8
0
84%

In mice, AMPK is linked to how the kidneys function.

8
0
84%

Mice missing the AMPKα1 gene produce more aldosterone in their urine and have lower blood pressure than normal mice.

8
0
73%