In mice, AMPK is linked to how the kidneys function.

Scientific Claim

In mice, AMPK activity is associated with kidney function.

Original Statement

“Thus we confirm the physiologically relevant role of AMPK in the kidney.”

Claim Status

overstated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The abstract uses 'confirm' which implies causation, but the study design (animal model without RCT) does not support causal claims.

Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

Cohort Study

Animal

2017 Feb 1

No contradicting evidence found

When mice lose both AMPKα1 and AMPKα2 in their kidneys, they lose too much water and salt in their urine.

84%

When mice lack the AMPKα1 gene, their kidneys handle salt normally and produce less urine than usual.

81%

Mice missing the AMPKα1 gene produce more aldosterone in their urine and have lower blood pressure than normal mice.

73%