In mice, AMPK is linked to how the kidneys function.

When mice lose both AMPKα1 and AMPKα2 in their kidneys, they lose too much water and salt in their urine.

When mice lack the AMPKα1 gene, their kidneys handle salt normally and produce less urine than usual.

Mice missing the AMPKα1 gene produce more aldosterone in their urine and have lower blood pressure than normal mice.

If we can turn on a certain switch in the body—using things like diet, exercise, or supplements—it might help our cells use sugar and fat better, clean out junk, reduce damage and swelling, and improve overall metabolism.