Your kidneys control how much fluid is in your blood by deciding whether to keep or get rid of salt and water.
Scientific Claim
Kidneys regulate blood volume by controlling sodium and water excretion.
Original Statement
“Blood volume is controlled by your kidneys, which decide how much sodium and water to hold on to or to excrete.”
Context Details
Domain
cardiology
Population
human
Subject
kidneys
Action
regulate
Target
blood volume via sodium and water excretion
Intervention Details
Evidence from Studies
Supporting (5)
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.
This research found that growing new lymphatic vessels in the kidneys can help remove excess salt and lower blood pressure.
Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.
This study shows that a specific protein in the kidneys helps control how much salt and water are reabsorbed into the body, which affects blood volume.
This study found that a protein controlled by the body's internal clock helps regulate how much salt is handled by the kidneys.
KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure
This research found that a specific enzyme in the kidneys helps control how much salt is excreted in the urine, which affects blood pressure.
Hormonal regulation of salt and water excretion: a mathematical model of whole kidney function and pressure natriuresis.
This study created a mathematical model to understand how the kidneys regulate salt and water levels in the body, which is important for controlling blood pressure.
Contradicting (2)
This research found that a certain medication lowered blood pressure, but it didn't seem to work by increasing salt excretion in the urine.
This research found that how much salt is excreted in the urine is related to the amount of fluid in the body, but not directly to blood pressure.