Kidney clock gene affects salt balance
Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Practical Takeaways
Monitor salt intake in sync with your body's natural rhythms for better blood pressure control
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Practical Takeaways
Monitor salt intake in sync with your body's natural rhythms for better blood pressure control
Publication
Journal
American journal of physiology. Renal physiology
Year
2022
Authors
Lauren G. Douma, Hannah M. Costello, G. Crislip, K. Cheng, I. J. Lynch, Alexandria Juffre, Dominique Barral, S. Masten, Emilio Roig, Kevin Beguiristain, Wendy Li, Phillip Bratanatawira, C. Wingo, M. Gumz
Related Content
Claims (6)
Kidneys regulate blood volume by controlling sodium and water excretion.
When mice have the PER1 protein removed specifically from their kidneys, they retain more salt when given a high-salt diet and a hormone treatment, which could affect blood pressure regulation. This finding is from the abstract summary - full study details were not available
When mice have the PER1 protein removed from their kidneys, their daily salt excretion rhythm stays normal even with a high-salt diet and hormone treatment. This finding is from the abstract summary - full study details were not available
Mice with kidney-specific PER1 removal show higher levels of a hormone that regulates salt and blood pressure. This finding is from the abstract summary - full study details were not available
Removing PER1 from mouse kidneys changes how genes related to body clock and stress hormones work in the adrenal glands. This finding is from the abstract summary - full study details were not available