Mice with kidney-specific PER1 removal show higher levels of a hormone that regulates salt and blood pressure. This finding is from the abstract summary - full study details were not available

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Supporting (1)

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Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.

Cohort Study

Animal

2022 Apr 1

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No contradicting evidence found

Source Study

Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.

Score: 8

DOI: 10.1152/ajprenal.00385.2021

Similar Assertions

Removing PER1 from mouse kidneys changes how genes related to body clock and stress hormones work in the adrenal glands. This finding is from the abstract summary - full study details were not available

80%

Mice with kidney-specific PER1 removal have higher levels of a kidney signaling molecule called endothelin-1. This finding is from the abstract summary - full study details were not available

71%

When mice have the PER1 protein removed from their kidneys, their daily salt excretion rhythm stays normal even with a high-salt diet and hormone treatment. This finding is from the abstract summary - full study details were not available

70%