descriptive
Analysis v1
8
0
Removing PER1 from mouse kidneys changes how genes related to body clock and stress hormones work in the adrenal glands. This finding is from the abstract summary - full study details were not available
Scientific Claim
Kidney-specific PER1 knockout in male mice is associated with altered expression of circadian clock and aldosterone synthesis genes in the adrenal gland.
Original Statement
“Adrenal gland gene expression analysis revealed that circadian clock and aldosterone synthesis genes have altered expression in KS-Per1 KO mice compared with control mice.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Based on abstract only - full methodology not available to verify. The study is an animal model without RCT design; 'associated with' correctly describes the observed relationship without implying causation.
Evidence from Studies
Supporting (1)
8
Contradicting (0)
0
No contradicting evidence found