Mice with kidney-specific PER1 removal have higher levels of a kidney signaling molecule called endothelin-1. This finding is from the abstract summary - full study details were not available

Scientific Claim

Kidney-specific PER1 knockout in male mice is associated with increased medullary endothelin-1 levels.

Original Statement

“increased medullary endothelin-1 compared with control mice”

From study:Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design cannot support claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

Based on abstract only - full methodology not available to verify. The study is an animal model without RCT design; 'associated with' correctly describes the observed relationship without implying causation.

Evidence from Studies

Supporting (1)

Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.

Cohort Study

Animal

2022 Apr 1

Contradicting (0)

No contradicting evidence found

Source Study

Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.

Score: 8

DOI: 10.1152/ajprenal.00385.2021

Similar Assertions

Mice with kidney-specific PER1 removal show higher levels of a hormone that regulates salt and blood pressure. This finding is from the abstract summary - full study details were not available

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