When mice have the PER1 protein removed from their kidneys, their daily salt excretion rhythm stays normal even with a high-salt diet and hormone treatment. This finding is from the abstract summary - full study details were not available

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design cannot support claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

Based on abstract only - full methodology not available to verify. The study is an animal model without RCT design; 'associated with' correctly describes the observed relationship without implying causation.

Evidence from Studies

Supporting (1)

Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.

Cohort Study

Animal

2022 Apr 1

Contradicting (0)

No contradicting evidence found

Source Study

Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.

Score: 8

DOI: 10.1152/ajprenal.00385.2021

Similar Assertions

When mice have the PER1 protein removed specifically from their kidneys, they retain more salt when given a high-salt diet and a hormone treatment, which could affect blood pressure regulation. This finding is from the abstract summary - full study details were not available

93%

Mice with kidney-specific PER1 removal show higher levels of a hormone that regulates salt and blood pressure. This finding is from the abstract summary - full study details were not available

70%

When rats had a part of their brain (SFO) removed, they kept less salt in their bodies during the first few days of eating a very salty diet, meaning that part of the brain helps control how the body handles extra salt.

70%