How a kidney gene affects blood pressure and aging
KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Klotho treatment reversed salt-sensitive hypertension caused by KDM6A deletion
While hypertension is often linked to diet or genetics, this shows a specific protein can reverse it even when caused by a genetic mutation in kidneys.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Klotho treatment reversed salt-sensitive hypertension caused by KDM6A deletion
While hypertension is often linked to diet or genetics, this shows a specific protein can reverse it even when caused by a genetic mutation in kidneys.
Publication
Journal
Hypertension
Year
2024
Authors
Xiaobin Han, Leah Akinseye, Zhongjie Sun
Related Content
Claims (6)
Kidneys regulate blood volume by controlling sodium and water excretion.
When mice lose the KDM6A gene in their kidney cells, their kidneys hold onto more salt and their blood pressure goes up, which might be linked to changes in a specific protein mark.
When mice lose the KDM6A gene in their kidneys, certain salt-handling proteins increase, which makes it harder for their kidneys to get rid of salt.
Mice missing the KDM6A gene in their kidneys show more water-absorbing proteins, which might make them hold onto more water.
Giving Klotho to mice with high blood pressure caused by missing the KDM6A gene in kidneys lowers their blood pressure back to normal.