Giving Klotho to mice with high blood pressure caused by missing the KDM6A gene in kidneys lowers their blood pressure back to normal.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure

Cohort Study

Animal

2024 Mar

Contradicting (0)

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No contradicting evidence found

Source Study

KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure

Score: 6

DOI: 10.1161/HYPERTENSIONAHA.123.22026

Similar Assertions

When mice lose the KDM6A gene in their kidney cells, their kidneys hold onto more salt and their blood pressure goes up, which might be linked to changes in a specific protein mark.

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