descriptive
Analysis v1
6
0
Giving Klotho to mice with high blood pressure caused by missing the KDM6A gene in kidneys lowers their blood pressure back to normal.
Scientific Claim
Salt-sensitive hypertension in mice with kidney-specific KDM6A deletion is reversed with Klotho treatment.
Original Statement
“KDM6A-cKO mice developed salt-sensitive hypertension which can be rescued by treatment with Klotho.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Based on abstract only - full methodology not available to verify. The abstract uses causal language ('rescued'), but the study is an animal model without explicit RCT design, so causation cannot be established.
Evidence from Studies
Supporting (1)
6
6
KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure
Cohort Study
Animal
2024 MarContradicting (0)
0
No contradicting evidence found