When mice lose the KDM6A gene in their kidney cells, their kidneys hold onto more salt and their blood pressure goes up, which might be linked to changes in a specific protein mark.
Scientific Claim
Kidney-specific deletion of KDM6A in mice is associated with increased H3K27me3 levels, decreased sodium excretion, and elevated blood pressure.
Original Statement
“conditional knockout of KDM6A gene in renal tubule cells (KDM6A-cKO) increased H3K27me3 levels which leads to a decrease in Na excretion and elevation of blood pressure.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Based on abstract only - full methodology not available to verify. The abstract uses causal language ('leads to'), but the study is an animal model without explicit RCT design, so causation cannot be established.
Evidence from Studies
Supporting (1)
KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure