When mice lose the KDM6A gene in their kidney cells, their kidneys hold onto more salt and their blood pressure goes up, which might be linked to changes in a specific protein mark.

Giving Klotho to mice with high blood pressure caused by missing the KDM6A gene in kidneys lowers their blood pressure back to normal.

When mice lose the KDM6A gene in their kidneys, certain salt-handling proteins increase, which makes it harder for their kidneys to get rid of salt.