When mice lose the KDM6A gene in their kidneys, certain salt-handling proteins increase, which makes it harder for their kidneys to get rid of salt.

When mice lose the KDM6A gene in their kidney cells, their kidneys hold onto more salt and their blood pressure goes up, which might be linked to changes in a specific protein mark.

Mice with extra kidney lymphatic vessels on a high-salt diet had lower levels of genes that control salt reabsorption in the kidneys.