Mice with extra kidney lymphatic vessels on a high-salt diet had lower levels of genes that control salt reabsorption in the kidneys.

Scientific Claim

During chronic salt loading, mice with kidney-specific lymphangiogenesis showed decreased mRNA expression of renal sodium transporters NCC, NKCC2, and NHE3.

Original Statement

“KidVD+ mice had significantly downregulated expression of the renal Na+ transporters Ncc, Nkcc2, and Nhe3 (Fig. 4g).”

From study:Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim uses 'showed decreased' which is appropriate for an association in an animal study, as causation cannot be established.

Evidence from Studies

Supporting (1)

Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Randomized Controlled Trial

Animal

2020 May

Contradicting (0)

No contradicting evidence found

Source Study

Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Score: 16

DOI: 10.1097/HJH.0000000000002349

Similar Assertions

When mice ate a high-salt diet, growing more lymphatic vessels in their kidneys lowered their blood sodium levels by about 4% compared to mice without extra lymphatic vessels.

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Mice with extra kidney lymphatic vessels on a high-salt diet excreted 64% more sodium in their urine compared to normal mice, helping them manage salt better.

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