Growing more lymphatic vessels in mouse kidneys during high-salt intake doubled the amount of fluid in the kidney tissue, acting like a sponge to hold extra fluid.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim uses 'associated with' and references the study's own description of 'almost two-fold', which is appropriate for this exploratory animal study.

Evidence from Studies

Supporting (1)

Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Randomized Controlled Trial

Animal

2020 May

Contradicting (0)

No contradicting evidence found

Source Study

Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Score: 16

DOI: 10.1097/HJH.0000000000002349

Similar Assertions

When mice ate a high-salt diet, growing more lymphatic vessels in their kidneys lowered their blood sodium levels by about 4% compared to mice without extra lymphatic vessels.

92%

Mice with extra kidney lymphatic vessels on a high-salt diet excreted 64% more sodium in their urine compared to normal mice, helping them manage salt better.

91%

When mice ate a normal diet, growing more lymphatic vessels in their kidneys didn't change how they handled salt or water.

82%

Mice with extra kidney lymphatic vessels on a high-salt diet had lower levels of genes that control salt reabsorption in the kidneys.

81%

When mice got a quick salt injection, extra kidney lymphatic vessels didn't change how much salt they excreted right away.

77%