When mice got a quick salt injection, extra kidney lymphatic vessels didn't change how much salt they excreted right away.

Scientific Claim

Acute sodium loading did not result in differences in urinary sodium excretion between mice with and without kidney-specific lymphangiogenesis (n=2-7 mice per group per hour).

Original Statement

“Hourly urinary total Na+ excretion was not different between KidVD− and KidVD+ mice (Fig. 3a), and similarly, there were no detectable changes in urine output (Fig. 3b).”

From study:Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim accurately describes the absence of effect observed in the study, which is appropriate for this evidence level.

Evidence from Studies

Supporting (1)

Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Randomized Controlled Trial

Animal

2020 May

Contradicting (0)

No contradicting evidence found

Source Study

Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Score: 16

DOI: 10.1097/HJH.0000000000002349

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