Mice with extra kidney lymphatic vessels on a high-salt diet excreted 64% more sodium in their urine compared to normal mice, helping them manage salt better.

Scientific Claim

In mice with chronic high salt loading, kidney-specific lymphangiogenesis was associated with a 63.7% higher urine sodium concentration (1003.6 ± 406.4 vs 613.6 ± 118 mmol/L) compared to controls.

Original Statement

“Urine Na+ (mmol/l): KidVD− 613.6 ± 118, KidVD+ 1003.6 ± 406.4a”

From study:Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim uses 'associated with' and includes specific numerical data from the study, which is appropriate for an animal study with small sample size.

Evidence from Studies

Supporting (1)

Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Randomized Controlled Trial

Animal

2020 May

Contradicting (0)

No contradicting evidence found

Source Study

Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

Score: 16

DOI: 10.1097/HJH.0000000000002349

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