quantitative
Analysis v1
16
0
When mice ate a high-salt diet, growing more lymphatic vessels in their kidneys lowered their blood sodium levels by about 4% compared to mice without extra lymphatic vessels.
Scientific Claim
During chronic high salt loading in mice, kidney-specific lymphangiogenesis was associated with a 4.1% lower serum sodium concentration (146.5 ± 3.5 vs 152.9 ± 3.9 mmol/L) compared to controls.
Original Statement
“Serum Na+ (mmol/l): KidVD− 152.9 ± 3.9, KidVD+ 146.5 ± 3.5a”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design (animal model with small n) can support association claims. The claim uses 'associated with' and includes specific numbers from the data, which is appropriate for this evidence level.
Evidence from Studies
Supporting (1)
16
16
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.
Randomized Controlled Trial
Animal
2020 MayContradicting (0)
0
No contradicting evidence found