When mice ate a normal diet, growing more lymphatic vessels in their kidneys didn't change how they handled salt or water.
Scientific Claim
Kidney-specific lymphangiogenesis in mice did not alter baseline sodium handling under normal salt conditions (no differences in urinary sodium excretion, urine output, fractional excretion, or creatinine clearance).
Original Statement
“KidVD+ mice did not exhibit changes in urinary Na+ excretion (Fig. 2c), urine output (Fig. 2d), fractional excretion of Na+ (Fig. 2e), or ClCr (Fig. 2f) compared with KidVD− mice.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim accurately describes the absence of effect observed in the study, which is appropriate for this evidence level.
Evidence from Studies
Supporting (1)
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.