descriptive
Analysis v1
6
0
Mice missing the KDM6A gene in their kidneys show more water-absorbing proteins, which might make them hold onto more water.
Scientific Claim
Increased AQP2 expression in mice with kidney-specific KDM6A deletion is associated with enhanced water reabsorption.
Original Statement
“The expression of AQP2 (aquaporin 2) was also increased in KDM6A-cKO mice, which may facilitate water reabsorption in KDM6A-cKO mice.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Based on abstract only - full methodology not available to verify. The abstract uses tentative language ('may facilitate'), but the study design cannot confirm causation.
Evidence from Studies
Supporting (1)
6
6
KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure
Cohort Study
Animal
2024 MarContradicting (0)
0
No contradicting evidence found