descriptive
Analysis v1
8
0
Even though these mice have less red blood cells, their blood plasma volume is higher than normal mice.
Scientific Claim
Plasma volume is increased in AMPKα1 knockout mice compared to wild-type mice despite lower hematocrit levels.
Original Statement
“Plasma volume, however, was found to be increased compared with wild-type mice. Thus blood volume is preserved despite a significantly lower hematocrit.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The abstract directly states the observation using 'increased' and 'lower', which are appropriate for descriptive claims in an animal model.
Evidence from Studies
Supporting (1)
8
8
Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.
Cohort Study
Animal
2017 Feb 1Contradicting (0)
0
No contradicting evidence found