Long-term high potassium intake in mice leads to higher levels of a hormone called aldosterone in both blood and urine.

Scientific Claim

Chronic high dietary potassium supplementation in mice is associated with elevated plasma and urinary aldosterone levels.

Original Statement

“Plasma [aldosterone] is increased following short-term and chronic KCl feeding. Urine aldosterone concentrations under the different chronic dietary K+ conditions.”

From study:Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports correlational claims. The phrasing correctly uses 'associated with' and specifies the measured hormone levels without implying causation.

Evidence from Studies

Supporting (1)

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Cohort Study

Animal

2023 Mar 8

Contradicting (0)

No contradicting evidence found

Source Study

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Score: 13

DOI: 10.1172/jci.insight.156437

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