Long-term high potassium intake in mice causes certain kidney tubules to shrink and others to grow larger.

Scientific Claim

Chronic high dietary potassium supplementation in mice is associated with distal convoluted tubule (DCT) atrophy and connecting tubule (CNT) hypertrophy.

Original Statement

“chronic NS/+KCl feeding reduced abundances of the DCT-specific protein parvalbumin, and both short-term and chronic NS/+KCl feeding increased abundance of the late DCT and CNT protein calbindin D28.”

From study:Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports correlational claims. The phrasing correctly uses 'associated with' and specifies the structural changes in kidney tubules without implying causation.

Evidence from Studies

Supporting (1)

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Cohort Study

Animal

2023 Mar 8

Contradicting (0)

No contradicting evidence found

Source Study

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Score: 13

DOI: 10.1172/jci.insight.156437

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