In mice, when aldosterone hits about 2701 pg/24h (a bit more than normal), the kidney's ENaC channels jump to their highest activity level.

Scientific Claim

In male mice, the relationship between aldosterone excretion and αENaC cleavage shows a steepest increase at approximately 2701 pg/24h aldosterone, corresponding to potassium intake just above the control level (0.75%).

Original Statement

“Aldosterone excretion was also positively correlated to both total and cleaved α-ENaC (Fig. 5E), with 4PL curve fitting showing the steepest rise in total and cleaved ENaC at ~2105 pg per 24 h aldosterone and ~2701 pg per 24 h, respectively”

From study:Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports correlational claims. The language accurately describes observed relationships without implying causation.

Evidence from Studies

Supporting (1)

Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC

Cohort Study

Animal

2025 Nov 17

Contradicting (0)

No contradicting evidence found

Source Study

Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC

Score: 13

DOI: 10.1038/s42003-025-08976-y

Similar Assertions

In mice, more potassium leads to more aldosterone in a straight-line way, but blood pressure rises sharply only when aldosterone hits a certain level (around 4040 pg/24h), then levels off.

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When mice eat more potassium on normal salt, their kidney's salt-handling channels change: one type (NCC) slows down but another (ENaC) speeds up, especially when aldosterone hits about 2701 pg/24h.

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When mice eat a lot of salt, adding a moderate amount of potassium lowers their blood pressure by about 3.6 mmHg compared to eating the same high salt without extra potassium.

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