When mice eat more potassium on normal salt, their kidney's salt-handling channels change: one type (NCC) slows down but another (ENaC) speeds up, especially when aldosterone hits about 2701 pg/24h.
Scientific Claim
On a normal salt diet, increased dietary potassium in male mice reduces NCC activity but increases αENaC cleavage, with the steepest rise in cleaved αENaC observed at aldosterone levels of approximately 2701 pg/24h.
Original Statement
“Aldosterone excretion was also positively correlated to both total and cleaved α-ENaC (Fig. 5E), with 4PL curve fitting showing the steepest rise in total and cleaved ENaC at ~2105 pg per 24 h aldosterone and ~2701 pg per 24 h, respectively”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design supports mechanistic associations. The claim describes observed protein changes without implying causation.
Evidence from Studies
Supporting (1)
Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC