When some guys get much bigger from weight training and others don’t, it’s not because the big responders have more of these male hormones inside their muscles — both groups have about the same levels, so something else must be causing the difference.
Claim Language
Language Strength
definitive
Uses definitive language (causes, prevents, cures)
The claim uses 'do not differ' and 'is not a primary driver,' which assert a definitive absence of effect rather than suggesting possibility or association. These phrases imply certainty about the lack of a causal role for androgens in hypertrophy variability.
Context Details
Domain
exercise_science
Population
human
Subject
high and low responders to resistance training in healthy, young, resistance-trained men
Action
do not differ
Target
intramuscular concentrations of free testosterone and dihydrotestosterone
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
The study found that even though some people gain more muscle than others from weight training, their muscle levels of testosterone and related hormones are the same — so it’s not the amount of hormone that matters, but how sensitive the muscle is to it.