Giving magnesium to depressed rats doesn't change the level of a specific brain protein called GAD-67 in a part of the brain called the hippocampus, so magnesium probably isn't working on that protein in that area.

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Brain glutamic acid decarboxylase-67 kDa alterations induced by magnesium treatment in olfactory bulbectomy and chronic mild stress models in rats

Cohort Study

Animal

2016 Oct

The study found that giving magnesium to depressed rats didn’t change a specific brain protein (GAD-67) in the hippocampus, but did change it in other brain areas. This means magnesium probably works on depression through other parts of the brain, not the hippocampus.

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Source Study

Brain glutamic acid decarboxylase-67 kDa alterations induced by magnesium treatment in olfactory bulbectomy and chronic mild stress models in rats

Score: 9

DOI: 10.1016/j.pharep.2016.04.011

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