Eating sugar substitutes like Splenda or Sweet'N Low doesn't seem to hurt your health, based on what we know now—even though some mouse studies saw gut changes when they gave way too much.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota.

Narrative Review

Human

2019 Feb

This study looked at artificial sweeteners and found that even though some mouse studies showed gut changes, those used way more sweetener than people ever eat — and humans didn’t show any harm. So, the sweeteners are probably safe at normal doses.

Contradicting (0)

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No contradicting evidence found

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Source Study

Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota.

Score: 1

DOI: 10.1016/j.fct.2018.12.005

Similar Assertions

When mice and rats eat artificial sweeteners like aspartame and sucralose for a long time, their gut bacteria get out of balance, lose variety, and start acting more inflammatory—which might explain why these sweeteners could make the body more prone to inflammation.

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The changes in gut bacteria seen in mice fed lots of saccharin happen only when they get way more than humans ever eat, so they don’t really tell us what happens when people use it.

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