Even though thyroxine causes a massive increase in the UCP1 protein in brown fat — over 30 times more — this does not significantly contribute to the overall rise in metabolism, meaning the hormone...

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Evidence from Studies

Supporting (1)

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At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1

Case-Control Study

Animal

2019 Jul

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1

Score: 13

DOI: 10.1016/j.molmet.2019.05.005