Even when your muscles don’t get as sore the second time you do a tough workout, your body still makes the same amount of protective proteins (HSP27 and HSP70) as it did the first time.

Context Details

Domain

exercise_science

Population

human

Subject

Intramuscular levels of HSP27 and HSP70 in humans

Action

increase similarly

Target

after both the first and second bouts of high-force eccentric exercise, despite reduced muscle damage after the second bout

Intervention Details

Type: exercise

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Evidence from Studies

Supporting (1)

31

The repeated bout effect and heat shock proteins: intramuscular HSP27 and HSP70 expression following two bouts of eccentric exercise in humans.

Cohort Study

Human

2002 Jan

Even though muscles got less hurt the second time they did the same tough exercise, the body still made just as much of these protective proteins (HSP27 and HSP70) as it did the first time.

Contradicting (0)

0

No contradicting evidence found

Source Study

The repeated bout effect and heat shock proteins: intramuscular HSP27 and HSP70 expression following two bouts of eccentric exercise in humans.

Score: 31

DOI: 10.1046/J.1365-201X.2002.00922.X

Similar Assertions

After you do a tough workout that stretches your muscles (like lowering weights slowly), your body gets better at handling the stress—so the next time, your muscles don’t need to produce as many protective proteins at rest.

31

0

85%

If you do a tough workout that stretches your muscles hard (like lowering weights slowly), then wait four weeks and do it again, your muscles won’t hurt as much or get as damaged the second time—they adapt and get tougher.

31

0

72%