The Claim
In post-menopausal or ovariectomized women aged 46–65, increasing doses of pulsatile human corticotropin-releasing hormone (0.5–2.0 µg/kg) do not alter the frequency or amplitude of luteinizing hormone pulses, while simultaneously increasing cortisol levels.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In women who have gone through menopause or had their ovaries removed, giving increasing doses of a specific hormone called corticotropin-releasing hormone raises cortisol levels but does not change how often or how strongly the body releases luteinizing hormone.
See the scientific wording
In post-menopausal or ovariectomized women aged 46–65, increasing doses of pulsatile human corticotropin-releasing hormone (0.5–2.0 µg/kg) do not change the frequency or amplitude of luteinizing hormone pulses, despite increasing cortisol levels.
When corticotropin-releasing hormone is released in pulses, it binds to receptors on pituitary cells that make stress hormones, causing those cells to release more stress hormone signals and increase cortisol production. At the same time, the brain cells that control reproductive hormone pulses do not respond to this signal, so the timing and strength of reproductive hormone pulses stay unchanged.
What the research says
1 studyWhen women after menopause were given increasing doses of a stress hormone trigger (CRH), their stress hormone (cortisol) went up, but their reproductive hormone pulses (LH) stayed exactly the same. So, even under stress, their reproductive signaling didn’t change.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.